Article
Expression and function of COOH-terminal myosin heavy chain isoforms in mouse smooth muscle.
American journal of physiology. Cell physiology - 1 Jul 2007
Martin Anne F, Bhatti Sunita, Pyne-Geithman Gail J, Farjah Mariam, Manaves Vlasios, Walker Lori, Franks Roberta, Strauch Arthur R, Paul Richard J
Abstract excerpt
Isoforms of the smooth muscle myosin motor, SM1 and SM2, differ in length at the carboxy terminal tail region. Their proportion changes with development, hormonal status and disease, but their function is unknown. We developed mice carrying the myosin heavy chain (MyHC) transgenes SM1, cMyc-tagged SM1, SM2, and V5-tagged SM2, and all transgenes corresponded to the SMa NH(2)-terminal isoform. Transgene expression...
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