Article
Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset.
Clinical and experimental immunology - 1 Jul 2004
Holm B C, Lorentzen J C, Bucht A
Abstract excerpt
A single intradermal injection of the adjuvant-oil squalene induces T cell mediated arthritis in DA rats. The chain of events leading from nonspecific provocation of the immune system to arthritis is largely unknown. Previous studies have demonstrated that lymph node (LN) cells are of pathogenic importance, i.e. cells from LNs draining the injection site can transfer arthritis to naïve DA rats. Recently we have...
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