A polymorphism of the 5' flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese.

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Article

A polymorphism of the 5' flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese.

Clinical endocrinology - 1 Jun 2000

Kamizono S, Hiromatsu Y, Seki N, Bednarczuk T, Matsumoto H, Kimura A, Itoh K

Abstract excerpt

OBJECTIVE: We have studied the polymorphism of the 5' flanking region of the tumour necrosis factor (TNF)-alpha gene in order to better understand the genetic background of autoimmune thyroid disorders and thyroid-associated ophthalmopathy. PATIENTS AND METHODS: We studied the polymorphism of the 5' flanking region of the TNF-alpha gene at positions - 1031 (T to C change, termed as - 1031C), - 863 (C to A, - 863...

Topics

5' Untranslated Regions
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Case-Control Studies
Female
Genetic Predisposition to Disease
Graves Disease
Humans
Japan
Male
Middle Aged
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 10848881

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Polymorphism, Genetic

Tumor Necrosis Factor-alpha