Article
Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease.
Clinical biochemistry - 1 Feb 2010
Gu Li-Qun, Zhu Wei, Pan Chun-Min, Zhao Lin, Zhang Min-Jia, Liu Jian-Min, Song Huai-Dong, Ning Guang, Zhao Yong-Ju
Abstract excerpt
OBJECTIVES: Tumor necrosis factor alpha (TNF-alpha) may play a central role in the development of Graves' disease (GD). The aim of this study was to investigate the association of TNF-alpha polymorphisms with GD in Chinese population. DESIGN AND METHODS: Genomic DNA was extracted from peripheral blood lymphocyte of 436 GD patients and 316 control subjects. TNF-alpha polymorphisms at positions -308 (G-308A,...
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