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Article

Baculoviral expressed HLA class I heavy chains used to screen a synthetic peptide library for allele-specific peptide binding motifs.

Molecular immunology - 1 Nov 1998

Smith M H, Nuara A A, Egen J G, Sirjani D B, Lam K S, Grimes W J

Abstract excerpt

Recombinant baculoviruses encoding truncated HLA-A*0101 and HLA-A*0201 class I heavy chains have been isolated and used to infect lepidopteran cells. Proteins overexpressed in this system were glycosylated, and consisted of 282 amino acid residues after signal sequence cleavage. These class I heavy chains could fold into their native conformation in the presence of recombinant human beta2-microglobulin expressed...

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Identifiers

PMID: 10068038
DOI: 10.1016/s0161-5890(98)00096-0

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