Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to intracellular dissociation from MHC class I:peptide complexes.

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Article

Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to intracellular dissociation from MHC class I:peptide complexes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1997

Levitsky V, Zhang Q J, Levitskaya J, Kurilla M G, Masucci M G

Abstract excerpt

EBV isolates from human populations with a high frequency of HLA A11 evade recognition by CTLs specific for an immunodominant A11-restricted epitope derived from the EBV nuclear antigen 4 (EBNA-4). We have previously described four nonimmunogenic variants of this epitope carrying single amino aci...

Topics

Cell Line, Transformed
Epstein-Barr Virus Nuclear Antigens
Genetic Variation
HLA-A Antigens
HLA-A11 Antigen
Histocompatibility Antigens Class I
Humans
Immunodominant Epitopes
Peptides
T-Lymphocytes, Cytotoxic

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Open in PubMed

Identifiers

PMID: 9548478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9548478-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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