Article
The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction.
Development genes and evolution - 1 Mar 1998
Schweisguth F, Lecourtois M
Abstract excerpt
Drosophila Hairless (H) encodes a negative regulator of Notch signalling. H activity antagonizes Notch (N) signalling during bristle development at the pupal stage. We show here by clonal analysis that H acts by inhibiting signal transduction rather than by promoting signal production, during bot...
Topics
- Animals
- Cell Differentiation
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Female
- Insect Proteins
- Male
- Membrane Proteins
- Mutation
- Pupa
- Receptors, Notch
- Repressor Proteins
- Signal Transduction
- Stem Cells
- Transcription Factors
- Wings, Animal