Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction.

Development genes and evolution - 1 Mar 1998

Schweisguth F, Lecourtois M

Abstract excerpt

Drosophila Hairless (H) encodes a negative regulator of Notch signalling. H activity antagonizes Notch (N) signalling during bristle development at the pupal stage. We show here by clonal analysis that H acts by inhibiting signal transduction rather than by promoting signal production, during both selection of microchaete precursors in the notum and vein cell differentiation in the wing. Allele-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Mutation

Share to Repressor Proteins

Share to Signal Transduction

Share to Transcription Factors

Source

Identifiers

PMID: 9518521
DOI: 10.1007/s004270050149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction.PMID 9518521Read ↗

Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Semantic proximity Read ↗

Hairless is required for the development of adult sensory organ precursor cells in Drosophila.Semantic proximity Read ↗

Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways.Semantic proximity Read ↗

Novel Genome-Engineered H Alleles Differentially Affect Lateral Inhibition and Cell Dichotomy Processes during Bristle Organ Development.Semantic proximity Read ↗

Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila.Semantic proximity Read ↗

Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster.Semantic proximity Read ↗

Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway.Semantic proximity Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

In vivo structure-function analysis of Drosophila Hairless.Semantic proximity Read ↗

Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.Semantic proximity Read ↗

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.Semantic proximity Read ↗

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.