Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of tests for association and linkage in incomplete families.

American journal of human genetics - 1 Jul 2000

Cervino A C, Hill A V

Abstract excerpt

To analyze incomplete families, the following statistical tests can be used: LRAT-a simple likelihood-based association test, TRANSMIT, SIBASSOC/STDT, and RCTDT. We compared these four tests, for the diallelic case, on simulated data sets. The comparisons focused on the power to detect linkage and association when different familial structures, resistance to population stratification, resistance to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bias
Share to Genes, Dominant
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, Inborn

Share to Likelihood Functions

Share to Nuclear Family

Share to Parents

Share to Research Design

Source

Open in PubMed Open full text

Identifiers

PMID: 10841813
DOI: 10.1086/302992
PMCID: PMC1287070

Genes

LRAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of tests for association and linkage in incomplete families.PMID 10841813Read ↗

Method for using complete and incomplete trios to identify genes related to a quantitative trait.Semantic proximity Read ↗

Transmission/disequilibrium test when neither parent is available in some families: a non-iterative approach.Semantic proximity Read ↗

Handling missing data in transmission disequilibrium test in nuclear families with one affected offspring.Semantic proximity Read ↗

Transmission disequilibrium test with discordant sib pairs when parents are available.Semantic proximity Read ↗

A robust TDT-type association test under informative parental missingness.Semantic proximity Read ↗

An evaluation of power and type I error of single-nucleotide polymorphism transmission/disequilibrium-based statistical methods under different family structures, missing parental data, and population stratification.Semantic proximity Read ↗

Testing informative missingness in genetic studies using case-parent triads.Semantic proximity Read ↗

A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test.Semantic proximity Read ↗

A discordant-sibship test for disequilibrium and linkage: no need for parental data.Semantic proximity Read ↗

Transmission disequilibrium test (TDT) when only one parent is available: the 1-TDT.Semantic proximity Read ↗

New approach to association testing in case-parent designs under informative parental missingness.Semantic proximity Read ↗

Genetic association analysis using sibship data: a multilevel model approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.