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Article

A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1.

Neuron - 1 May 2000

Kim H A, Pomeroy S L, Whoriskey W, Pawlitzky I, Benowitz L I, Sicinski P, Stiles C D, Roberts T M

Abstract excerpt

Sciatic nerve axons in cyclin D1 knockout mice develop normally, become properly ensheathed by Schwann cells, and appear to function normally. However, in the Wallerian degeneration model of nerve injury, the mitotic response of Schwann cells is completely inhibited. The mitotic block is Schwann cell autonomous and developmentally regulated. Rescue analysis (by "knockin" of cyclin E) indicates that D1 protein,...

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PMID: 10839359
DOI: 10.1016/s0896-6273(00)81173-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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