Article
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Proceedings of the National Academy of Sciences of the United States of America - 5 Nov 2013
Grigoryan Tamara, Stein Simone, Qi Jingjing, Wende Hagen, Garratt Alistair N, Nave Klaus-Armin, Birchmeier Carmen, Birchmeier Walter
Abstract excerpt
During late Schwann cell development, immature Schwann cells segregate large axons from bundles, a process called "axonal radial sorting." Here we demonstrate that canonical Wnt signals play a critical role in radial sorting and assign a role to Wnt and Rspondin ligands in this process. Mice carrying β-catenin loss-of-function mutations show a delay in axonal sorting; conversely, gain-of-function mutations result...
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