Article
ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2006
Atanasoski Suzana, Scherer Steven S, Sirkowski Erich, Leone Dino, Garratt Alistair N, Birchmeier Carmen, Suter Ueli
Abstract excerpt
Neuregulin/erbB signaling is critically required for survival and proliferation of Schwann cells as well as for establishing correct myelin thickness of peripheral nerves during development. In this study, we investigated whether erbB2 signaling in Schwann cells is also essential for the maintenance of myelinated peripheral nerves and for Schwann cell proliferation and survival after nerve injury. To this end, we...
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