Article
Mutations in dock1 disrupt early Schwann cell development.
Neural development - 8 Aug 2018
Cunningham Rebecca L, Herbert Amy L, Harty Breanne L, Ackerman Sarah D, Monk Kelly R
Abstract excerpt
BACKGROUND: In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During development, Schwann cells must undergo extensive cytoskeletal rearrangements in order to become mature, myelinating Schwann cells. The intracellular mechanisms that drive Schwann cell...
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