Article
Anti-tumor vaccination in heterozygous congenic F1 mice: presentation of tumor-associated antigen by the two parental class I alleles.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Carmon L, Tzehoval E, Tirosh B, el-Shami K M, Bar-Haim E, Vadai E, Feldman M, Eisenbach L
Abstract excerpt
Peptide vaccination of homozygous mice against syngeneic tumors using single major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocyte (CTL) epitopes elicits effective immune responses against metastatic growth. So far, single-peptide vaccination of patients against their autologous tumors seems to elicit less satisfactory results. In this study, the authors tried to determine whether...
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