Article
The growth rate of two transplantable murine tumors, 3LL lung carcinoma and B16F10 melanoma, is influenced by Hyal-1, a locus determining hyaluronidase levels and polymorphism.
International journal of cancer - 19 Jun 1992
De Maeyer E, De Maeyer-Guignard J
Abstract excerpt
The effect of 2 different levels of serum hyaluronidase on tumor development was studied by comparing the development of 2 transplantable tumors, the 3LL lung carcinoma and the B16F10 melanoma, in mice of the C57BL/6 and the congenic HW23 strains. The reasoning behind the study was that, in vitro, removal by hyaluronidase of the hyaluronan present in the extracellular matrix of tumor cells renders the latter more...
Topics
- Alleles
- Animals
- Cell Division
- Cell Line
- Genetic Predisposition to Disease
- Hyaluronoglucosaminidase
- Lung Neoplasms
- Melanoma
- Mice
- Mice, Inbred C57BL