Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.

The Journal of experimental medicine - 7 Dec 1998

Ceman S, Wu S, Jardetzky T S, Sant A J

Abstract excerpt

To characterize the importance of a highly conserved region of the class II beta chain, we introduced an amino acid substitution that is predicted to eliminate a hydrogen bond formed between the class II molecule and peptide. We expressed the mutated beta chain with a wild-type alpha chain in a murine L cell by gene transfection. The mutant class II molecule (81betaH-) assembles normally in the endoplasmic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, MHC Class II

Share to Histocompatibility Antigens Class II

Share to Mutation

Share to Protein Conformation

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 9841927
DOI: 10.1084/jem.188.11.2139
PMCID: PMC2212374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.PMID 9841927Read ↗

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties.Semantic proximity Read ↗

Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules.Semantic proximity Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange.Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.Semantic proximity Read ↗

Structural principles of MHC class II antigen presentation.Semantic proximity Read ↗

A general model of invariant chain association with class II major histocompatibility complex proteins.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.