Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.

doi:10.1084/jem.188.11.2139

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Article

Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.

The Journal of experimental medicine - 7 Dec 1998

Ceman S, Wu S, Jardetzky T S, Sant A J

Abstract excerpt

To characterize the importance of a highly conserved region of the class II beta chain, we introduced an amino acid substitution that is predicted to eliminate a hydrogen bond formed between the class II molecule and peptide. We expressed the mutated beta chain with a wild-type alpha chain in a m...

Topics

Amino Acid Substitution
Animals
Cell Line
Genes, MHC Class II
Histocompatibility Antigens Class II
Hydrogen
Mice
Mutation
Protein Conformation
Structure-Activity Relationship

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