Article
Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias.
Experimental & molecular medicine - 30 Jun 2004
Minamisawa Susumu, Sato Yoji, Cho Myeong-Chan
Abstract excerpt
A growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca2+ cycling and Ca2+-dependent signaling pathways play a pivotal role in cardiac hypertrophy and heart failure. In addition, recent studies identified that mutations of the genes encoding sarcoplasmic reticulum (SR) proteins cause human cardiomyopathies and lethal ventricular arrhythmias. The regulation of...
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