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Article

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

Genes & development - 15 Apr 2017

Natsume Toyoaki, Nishimura Kohei, Minocherhomji Sheroy, Bhowmick Rahul, Hickson Ian D, Kanemaki Masato T

Abstract excerpt

DNA replication fork progression can be disrupted at difficult to replicate loci in the human genome, which has the potential to challenge chromosome integrity. This replication fork disruption can lead to the dissociation of the replisome and the formation of DNA damage. To model the events stemming from replisome dissociation during DNA replication perturbation, we used a degron-based system for inducible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28487407
DOI: 10.1101/gad.297663.117
PMCID: PMC5435893

Genes

MCM8
MCM2
RAD51
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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