Article
In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice.
Naunyn-Schmiedeberg's archives of pharmacology - 1 May 2000
Rueter L E, Tecott L H, Blier P
Abstract excerpt
The present study used 5-HT2C receptor mutant mice and their wild-type littermates to characterize the 5-HT2 receptor using the 5-HT2 agonists (+/-)-2-dimethoxy-4-iodoamphetamine hydrochloride (DOI) and 1-(3-chlorophenyl)piperazine (mCPP) applied locally in the orbitofrontal cortex (OFC) and head of the caudate nucleus. Microiontophoretically-applied 5-HT, DOI and mCPP induced current-dependent inhibition of...
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