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Article

D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011

Li Yan-Chun, Kellendonk Christoph, Simpson Eleanor H, Kandel Eric R, Gao Wen-Jun

Abstract excerpt

Two distinct defects are thought to be important for the pathophysiology of schizophrenia. One is an increase of D2 receptors (D2Rs) in the striatum and another is a decrease in the GABAergic function in the prefrontal cortex (PFC). Whether these two defects are functionally linked is not known. We previously reported that selective overexpression of D2Rs in the striatum of the mouse causes behavioral abnormality...

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Identifiers

PMID: 21730148
DOI: 10.1073/pnas.1109718108
PMCID: PMC3141950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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