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Article

Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice.

PloS one - 1 Jan 2014

Hazama Keisuke, Hayata-Takano Atsuko, Uetsuki Kazuki, Kasai Atsushi, Encho Naoki, Shintani Norihito, Nagayasu Kazuki, Hashimoto Ryota, Reglodi Dora, Miyakawa Tsuyoshi, Nakazawa Takanobu, Baba Akemichi, Hashimoto Hitoshi

Abstract excerpt

Accumulating evidence from human genetic studies implicates the pituitary adenylate cyclase-activating polypeptide (PACAP) gene as a risk factor for psychiatric disorders, including schizophrenia and stress-related diseases. Mice with homozygous disruption of the PACAP gene display profound behavioral and neurological abnormalities that are ameliorated with the atypical antipsychotic and dopamine D2 and serotonin...

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Identifiers

PMID: 24586556
DOI: 10.1371/journal.pone.0089153
PMCID: PMC3930680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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