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Article

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

15 Aug 1997

Abstract excerpt

Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified. Disruption of the S. pombe gene resulted in telomere shortening and senescence, and expression of mRNA from the human gene correlated with telomerase activity...

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Identifiers

PMID: 9252327
DOI: 10.1126/science.277.5328.955

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