Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNase P/MRP subunits chaperone telomerase holoenzyme assembly in fission yeast.

EMBO reports - 1 Jun 2026

Pan Lili, Patterson Valentine, Möckel Martin M, Helston Rachel M, Wellinger Raymund J, Zappulla David C, Baumann Peter

Abstract excerpt

Telomerase biogenesis is a multistep process requiring the coordinated action of several accessory factors. In the fission yeast Schizosaccharomyces pombe, the telomerase RNA TER1 undergoes spliceosome-mediated 3'-end processing, followed by association with the Pof8/Bmc1/Thc1 complex, which facilitates binding of the Lsm2-8 complex. Lsm2-8 protects TER1 from nucleolytic degradation and promotes recruitment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Holoenzymes
Share to Molecular Chaperones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Subunits

Share to Endoribonucleases

Share to Ribonuclease P

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 42049898
DOI: 10.1038/s44319-026-00782-9
PMCID: PMC13303942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNase P/MRP subunits chaperone telomerase holoenzyme assembly in fission yeast.PMID 42049898Read ↗

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read ↗

LARP7 family proteins have conserved function in telomerase assemblySemantic proximity Read ↗

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationSemantic proximity Read ↗

Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.Semantic proximity Read ↗

The fission yeast methyl phosphate capping enzyme Bmc1 guides 2’-O-methylation of the U6 snRNASemantic proximity Read ↗

Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ CellsSemantic proximity Read ↗

Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe.Semantic proximity Read ↗

TER1, the RNA subunit of fission yeast telomerase.Semantic proximity Read ↗

Two separation-of-function isoforms of human TPP1 and a novel intragenic noncoding RNA dictate telomerase regulation in somatic and germ cellsSemantic proximity Read ↗

Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.Semantic proximity Read ↗

Unraveling the stepwise maturation of the yeast telomerase including a Cse1 and Mtr10 mediated quality control checkpoint.Semantic proximity Read ↗

PES1 is a critical component of telomerase assembly and regulates cellular senescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.