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Article

Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.

Molecular and cellular biology - 1 Jun 2000

Zhurinsky J, Shtutman M, Ben-Ze'ev A

Abstract excerpt

beta-Catenin and plakoglobin are highly homologous components of cell-cell adherens junctions linking cadherin receptors to the actin cytoskeleton. beta-Catenin, in addition, activates transcription by forming a complex with LEF/TCF family transcription factors in the nucleus. Plakoglobin can also bind to LEF-1 and, when overexpressed in mammalian cells, enhances LEF-1-directed transcription. Plakoglobin...

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Source

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Identifiers

PMID: 10825188
DOI: 10.1128/MCB.20.12.4238-4252.2000
PMCID: PMC85792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.PMID 10825188Read ↗

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