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Article

Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.

Oncogene - 4 Dec 1997

Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P

Abstract excerpt

Signal transduction by beta-catenin involves its posttranslational stabilization and import to the nucleus where it interacts with transcription factors. Recent implications for beta-catenin signaling in cancer prompted us to examine colon cancer cell lines for the expression of LEF-1, a transcri...

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Source

Identifiers

PMID: 9419974
DOI: 10.1038/sj.onc.1201462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9419974-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.PMID 9419974Read ↗

Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.Semantic proximity Read ↗

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferationSemantic proximity Read ↗

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell linesSemantic proximity Read ↗

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival of multiple human colorectal cancer cell linesSemantic proximity Read ↗

Wnt signaling and colon carcinogenesis: Beyond APCSemantic proximity Read ↗

SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferationSemantic proximity Read ↗

E-cadherin can limit the transforming properties of activating β-catenin mutations.Semantic proximity Read ↗

LEF-1 is frequently expressed in colorectal carcinoma and not in other gastrointestinal tract adenocarcinomas: an immunohistochemical survey of 602 gastrointestinal tract neoplasms.Semantic proximity Read ↗

The oncogenic activation of beta-catenin.Semantic proximity Read ↗

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.Semantic proximity Read ↗

Beta-catenin: a transforming actor on many stages.Semantic proximity Read ↗

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signalingSemantic proximity Read ↗

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