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Article

Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.

Oncogene - 4 Dec 1997

Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P

Abstract excerpt

Signal transduction by beta-catenin involves its posttranslational stabilization and import to the nucleus where it interacts with transcription factors. Recent implications for beta-catenin signaling in cancer prompted us to examine colon cancer cell lines for the expression of LEF-1, a transcription factor that binds to beta-catenin. The analysis of several cell lines revealed the expression of LEF1 mRNA and a...

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Source

Identifiers

PMID: 9419974
DOI: 10.1038/sj.onc.1201462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.PMID 9419974Read ↗

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Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell linesSemantic proximity Read ↗

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival of multiple human colorectal cancer cell linesSemantic proximity Read ↗

Wnt signaling and colon carcinogenesis: Beyond APCSemantic proximity Read ↗

SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferationSemantic proximity Read ↗

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The oncogenic activation of beta-catenin.Semantic proximity Read ↗

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