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Article

Defining the roles of beta-catenin and plakoglobin in LEF/T-cell factor-dependent transcription using beta-catenin/plakoglobin-null F9 cells.

Molecular and cellular biology - 1 Jan 2008

Shimizu Masayuki, Fukunaga Yoshitaka, Ikenouchi Junichi, Nagafuchi Akira

Abstract excerpt

beta-Catenin functions as a transcriptional regulator in Wnt signaling. Its function is regulated by a specific destruction system. Plakoglobin is a close homologue of beta-catenin in mammalian cells and is regulated in a similar fashion. When beta-catenin or plakoglobin is exogenously expressed in cells, endogenous beta-catenin is stabilized, which complicates estimation of the transcriptional activities of...

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Identifiers

PMID: 17984222
DOI: 10.1128/MCB.02375-06
PMCID: PMC2223424

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