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Article

Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.

Genes & development - 15 Dec 2001

Tutter A V, Fryer C J, Jones K A

Abstract excerpt

Transcriptional activation of Wnt/Wg-responsive genes requires the stabilization and nuclear accumulation of beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins. Here we report that recombinant beta-catenin strongly enhances binding and transactivation by LEF-1 on chromatin templates in vitro. Interestingly, different LEF-1 isoforms vary in their ability to bind nucleosomal templates in the...

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Source

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Identifiers

PMID: 11751639
DOI: 10.1101/gad.946501
PMCID: PMC312851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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