Limits of neutral drift: lessons from the in vitro evolution of two ribozymes.

doi:10.1007/s00239-014-9642-z

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Article

Limits of neutral drift: lessons from the in vitro evolution of two ribozymes.

Journal of molecular evolution - 1 Oct 2014

Petrie Katherine L, Joyce Gerald F

Abstract excerpt

The relative contributions of adaptive selection and neutral drift to genetic change are unknown but likely depend on the inherent abundance of functional genotypes in sequence space and how accessible those genotypes are to one another. To better understand the relative roles of selection and dr...

Topics

Base Sequence
Evolution, Molecular
Founder Effect
Genetic Drift
Genetic Fitness
Genotype
Models, Genetic
Molecular Sequence Data
Mutation Rate
Nucleic Acid Conformation
RNA, Catalytic
Sequence Analysis, DNA

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