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Article

Limits of neutral drift: lessons from the in vitro evolution of two ribozymes.

Journal of molecular evolution - 1 Oct 2014

Petrie Katherine L, Joyce Gerald F

Abstract excerpt

The relative contributions of adaptive selection and neutral drift to genetic change are unknown but likely depend on the inherent abundance of functional genotypes in sequence space and how accessible those genotypes are to one another. To better understand the relative roles of selection and drift in evolution, local fitness landscapes for two different RNA ligase ribozymes were examined using a continuous in...

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Identifiers

PMID: 25155818
DOI: 10.1007/s00239-014-9642-z
PMCID: PMC4185262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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