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Article

A genotype-to-phenotype map of in vitro selected RNA-cleaving DNAzymes: implications for accessing the target phenotype.

Nucleic acids research - 1 Jun 2009

Schlosser Kenny, Lam Jeffrey C F, Li Yingfu

Abstract excerpt

Herein, we describe a case study into the population dynamics of in vitro selection, using RNA-cleaving DNAzymes as a model system. We sought to understand how the composition of the population can change over time in response to different levels of selection pressure, and how well these changes are correlated with selection of the target phenotype. The model population is composed of 857 DNAzyme clones...

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Identifiers

PMID: 19357090
DOI: 10.1093/nar/gkp222
PMCID: PMC2699508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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