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Article

Interaction of Shigella flexneri IpaC with model membranes correlates with effects on cultured cells.

Infection and immunity - 1 Jun 2000

Tran N, Serfis A B, Osiecki J C, Picking W L, Coye L, Davis R, Picking W D

Abstract excerpt

Invasion of enterocytes by Shigella flexneri requires the properly timed release of IpaB and IpaC at the host-pathogen interface; however, only IpaC has been found to possess quantifiable activities in vitro. We demonstrate here that when added to cultured cells, purified IpaC elicits cytoskeletal changes similar to those that occur during Shigella invasion. This IpaC effect may correlate with its ability to...

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10816532
DOI: 10.1128/IAI.68.6.3710-3715.2000
PMCID: PMC97663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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