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Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore

14 Nov 2019

Abstract excerpt

Type 3 secretion systems (T3SSs) are conserved bacterial nanomachines that inject virulence proteins (effectors) into eukaryotic cells during infection. Due to their ability to inject heterologous proteins into human cells, these systems are being developed as therapeutic delivery devices. The T3SS assembles a translocon pore in the plasma membrane and then docks onto the pore. Docking activates effector...

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PMID: 31725799
DOI: 10.1371/journal.ppat.1007928

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