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Article

Intricate role of water in proton transport through cytochrome c oxidase.

Journal of the American Chemical Society - 17 Nov 2010

Lee Hyun Ju, Svahn Emelie, Swanson Jessica M J, Lepp Håkan, Voth Gregory A, Brzezinski Peter, Gennis Robert B

Abstract excerpt

Cytochrome c oxidase (CytcO), the final electron acceptor in the respiratory chain, catalyzes the reduction of O(2) to H(2)O while simultaneously pumping protons across the inner mitochondrial or bacterial membrane to maintain a transmembrane electrochemical gradient that drives, for example, ATP synthesis. In this work mutations that were predicted to alter proton translocation and enzyme activity in preliminary...

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Identifiers

PMID: 20964330
DOI: 10.1021/ja107244g
PMCID: PMC3005615

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Source receipt: pubmed, retrieved 7 Sept 2026.

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