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Article

Subunit III-depleted cytochrome c oxidase provides insight into the process of proton uptake by proteins.

Biochimica et biophysica acta - 1 Apr 2012

Varanasi Lakshman, Hosler Jonathan P

Abstract excerpt

We review studies of subunit III-depleted cytochrome c oxidase (CcO III (-)) that elucidate the structural basis of steady-state proton uptake from solvent into an internal proton transfer pathway. The removal of subunit III from R. sphaeroides CcO makes proton uptake into the D pathway a rate-determining step, such that measurements of the pH dependence of steady-state O(2) consumption can be used to compare the...

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Identifiers

PMID: 22023935
DOI: 10.1016/j.bbabio.2011.10.001
PMCID: PMC3294125

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