Article
Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes.
Cancer research - 1 May 2000
Moser M J, Bigbee W L, Grant S G, Emond M J, Langlois R G, Jensen R H, Oshima J, Monnat R J
Abstract excerpt
Werner syndrome (WRN) is an uncommon autosomal recessive disease in which progeroid features are associated with genetic instability and an elevated risk of neoplasia. We have used the glycophorin A (GPA) somatic cell mutation assay to analyze genetic instability in vivo in WRN patients and heterozygotes. GPA variant frequencies were determined for 11 WRN patients and for 10 heterozygous family members who...
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