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Article

Werner syndrome gene variants in human sarcomas.

Molecular carcinogenesis - 1 Feb 2010

Hsu Jessica J, Kamath-Loeb Ashwini S, Glick Eitan, Wallden Brett, Swisshelm Karen, Rubin Brian P, Loeb Lawrence A

Abstract excerpt

Werner syndrome is an autosomal inherited disease that is characterized by premature aging. The gene mutated in Werner syndrome (WS), WRN, encodes both a 3' --> 5' DNA helicase and a 3' --> 5' DNA exonuclease. Among the WS phenotypes is an exceptionally high incidence of sarcomas. We asked whether spontaneous sarcomas, not known to be associated with WS, also harbor mutations or unreported single nucleotide...

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Identifiers

PMID: 19824023
DOI: 10.1002/mc.20586
PMCID: PMC2813347

Genes

WRN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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