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Article

Werner syndrome through the lens of tissue and tumour genomics.

Scientific reports - 25 Aug 2016

Tokita Mari, Kennedy Scott R, Risques Rosa Ana, Chun Stephen G, Pritchard Colin, Oshima Junko, Liu Yan, Bryant-Greenwood Peter K, Welcsh Piri, Monnat Raymond J

Abstract excerpt

Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tumors have been performed to provide insight into WS disease pathogenesis or the high risk of...

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Identifiers

PMID: 27559010
DOI: 10.1038/srep32038
PMCID: PMC4997333

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