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Article

Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase.

The Journal of biological chemistry - 19 May 2000

Souza R L, Green-Willms N S, Fox T D, Tzagoloff A, Nobrega F G

Abstract excerpt

Nuclear mutants of Saccharomyces cerevisiae assigned to complementation group G34 are respiratory-deficient and lack cytochrome oxidase activity and the characteristic spectral peaks of cytochromes a and a(3). The corresponding gene was cloned by complementation, sequenced, and identified as reading frame YGR062C on chromosome VII. This gene was named COX18. The COX18 gene product is a polypeptide of 316 amino...

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Source

Identifiers

PMID: 10809734
DOI: 10.1074/jbc.275.20.14898

Genes

COX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase.PMID 10809734Read ↗

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Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.Semantic proximity Read ↗

Cloning and characterization of KlCOX18, a gene required for activity of cytochrome oxidase in Kluyveromyces lactis.Semantic proximity Read ↗

Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.Semantic proximity Read ↗

COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase.Semantic proximity Read ↗

COX10 codes for a protein homologous to the ORF1 product of Paracoccus denitrificans and is required for the synthesis of yeast cytochrome oxidase.Semantic proximity Read ↗

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