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Article

Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.

The Journal of biological chemistry - 14 Jun 1996

Glerum D M, Shtanko A, Tzagoloff A

Abstract excerpt

Mutations in the COX17 gene of Saccharomyces cerevisiae cause a respiratory deficiency due to a block in the production of a functional cytochrome oxidase complex. Because cox17 mutants are able to express both the mitochondrially and nuclearly encoded subunits of cytochrome oxidase, the Cox17p most likely affects some late posttranslational step of the assembly pathway. A fragment of yeast nuclear DNA capable of...

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Source

Identifiers

PMID: 8662933
DOI: 10.1074/jbc.271.24.14504

Genes

COX17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.PMID 8662933Read ↗

Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment.Semantic proximity Read ↗

COX23, a homologue of COX17, is required for cytochrome oxidase assembly.Semantic proximity Read ↗

Cox17 is functional when tethered to the mitochondrial inner membrane.Semantic proximity Read ↗

Mutagenesis reveals a specific role for Cox17p in copper transport to cytochrome oxidase.Semantic proximity Read ↗

Characterization of COX19, a widely distributed gene required for expression of mitochondrial cytochrome oxidase.Semantic proximity Read ↗

Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.Semantic proximity Read ↗

AtCOX17, an Arabidopsis homolog of the yeast copper chaperone COX17.Semantic proximity Read ↗

Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase.Semantic proximity Read ↗

Mutational analysis of the Saccharomyces cerevisiae cytochrome c oxidase assembly protein Cox11p.Semantic proximity Read ↗

Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis.Semantic proximity Read ↗

Cloning and characterization of COX14, whose product is required for assembly of yeast cytochrome oxidase.Semantic proximity Read ↗

Characterization of the peroxide sensitivity of COX-deficient yeast strains reveals unexpected relationships between COX assembly proteins.Semantic proximity Read ↗

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