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Article

Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.

Molecular biology of the cell - 1 Apr 2002

Saracco Scott A, Fox Thomas D

Abstract excerpt

The amino- and carboxy-terminal domains of mitochondrially encoded cytochrome c oxidase subunit II (Cox2p) are translocated out of the matrix to the intermembrane space. We have carried out a genetic screen to identify components required to export the biosynthetic enzyme Arg8p, tethered to the Cox2p C terminus by a translational gene fusion inserted into mtDNA. We obtained multiple alleles of COX18, PNT1, and...

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Identifiers

PMID: 11950926
DOI: 10.1091/mbc.01-12-0580
PMCID: PMC102256

Genes

COX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.PMID 11950926Read ↗

Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase.Semantic proximity Read ↗

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A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression.Semantic proximity Read ↗

Biallelic variants in<i>COX18</i>cause a mitochondrial disorder primarily manifesting as peripheral neuropathySemantic proximity Read ↗

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Cox17 is functional when tethered to the mitochondrial inner membrane.Semantic proximity Read ↗

Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.Semantic proximity Read ↗

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