Article
Analysis of COX2 mutants reveals cytochrome oxidase subassemblies in yeast.
The Biochemical journal - 15 Sept 2005
Horan Susannah, Bourges Ingrid, Taanman Jan-Willem, Meunier Brigitte
Abstract excerpt
Cytochrome oxidase catalyses the reduction of oxygen to water. The mitochondrial enzyme contains up to 13 subunits, 11 in yeast, of which three, Cox1p, Cox2p and Cox3p, are mitochondrially encoded. The assembly pathway of this complex is still poorly understood. Its study in yeast has been so far impeded by the rapid turnover of unassembled subunits of the enzyme. In the present study, immunoblot analysis of blue...
Topics
- Electron Transport Complex IV
- Mutation
- Protein Subunits
- Saccharomyces cerevisiae