Article
Characterization of COX19, a widely distributed gene required for expression of mitochondrial cytochrome oxidase.
The Journal of biological chemistry - 25 Oct 2002
Nobrega Marina P, Bandeira Simone C B, Beers John, Tzagoloff Alexander
Abstract excerpt
COX19, a nuclear gene of Saccharomyces cerevisiae, was cloned by transformation of a respiratory-deficient mutant from complementation group G188 of a pet mutant collection. The gene codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Electron Transport Complex IV
- Gene Expression Regulation, Enzymologic
- Humans
- Mitochondria
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid
- Subcellular Fractions