Article
Tumor necrosis factor gene complex in COPD and disseminated bronchiectasis.
Chest - 1 May 2000
Patuzzo C, Gilè L S, Zorzetto M, Trabetti E, Malerba G, Pignatti P F, Luisetti M
Abstract excerpt
BACKGROUND: Tumor necrosis factor (TNF) is a potent proinflammatory cytokine with increased levels in the sputum of COPD subjects. Two biallelic TNF gene complex polymorphisms have been described: LtalphaNcoI, in the first intron of the lymphotoxin alpha (previously referred to as TNF-beta) gene, and TNF-308, in the promoter region of the TNF-alpha gene. Higher levels of TNF production are associated with allele...
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