Article
A high incidence of Shigella-induced arthritis in a primate species: major histocompatibility complex class I molecules associated with resistance and susceptibility, and their relationship to HLA-B27.
Immunogenetics - 1 Apr 2000
Urvater J A, McAdam S N, Loehrke J H, Allen T M, Moran J L, Rowell T J, Rojo S, López de Castro J A, Taurog J D, Watkins D I
Abstract excerpt
The human major histocompatibility complex (MHC) class I gene, HLA-B27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies. Rodents that express HLA-B27 develop spondyloarthropathies, implicating HLA-B27 in the etiology of these disorders. To determine whether an HLA-B27-like molecule was associated with spondyloarthropathies in nonhuman primates, we analyzed the MHC...
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