Article
Gorillas with spondyloarthropathies express an MHC class I molecule with only limited sequence similarity to HLA-B27 that binds peptides with arginine at P2.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2001
Urvater J A, Hickman H, Dzuris J L, Prilliman K, Allen T M, Schwartz K J, Lorentzen D, Shufflebotham C, Collins E J, Neiffer D L, Raphael B, Hildebrand W, Sette A, Watkins D I
Abstract excerpt
The human MHC class I gene, HLA-B27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies (SpAs). HLA-B27-transgenic rodents develop SpAs, implicating HLA-B27 in the etiology of these disorders. Several nonhuman primates, including gorillas, develop signs of SpAs indistinguishable from clinical signs of humans with SpAs. To determine whether SpAs in gorillas have a...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Arginine
- Arthritis
- Cells, Cultured
- Female
- Genetic Predisposition to Disease
- Gorilla gorilla
- HLA-B27 Antigen