Molecular Mimicry of an HLA-B27-derived Ligand of Arthritis-linked Subtypes with Chlamydial Proteins

Abstract excerpt

HLA-B27 is strongly associated with spondyloarthropathies, including ankylosing spondylitis and reactive arthritis. The latter disease is triggered by various Gram-negative bacteria. A dodecamer derived from the intracytoplasmic tail of HLA-B27 was a natural ligand of three disease-associated subtypes (B*2702, B*2704, and B*2705) but not of two (B*2706 and B*2709), weakly or not associated to spondyloarthropathy....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Reproductive System and Pregnancy
• Share to Spondyloarthritis Studies and Treatments
• Share to T-cell and B-cell Immunology