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Article

Inflammatory disease in HLA-B27 transgenic rats.

Immunological reviews - 1 Jun 1999

Taurog J D, Maika S D, Satumtira N, Dorris M L, McLean I L, Yanagisawa H, Sayad A, Stagg A J, Fox G M, Lê O'Brien A, Rehman M, Zhou M, Weiner A L, Splawski J B, Richardson J A, Hammer R E

Abstract excerpt

UNLABELLED: A spontaneous inflammatory disease in rats transgenic for HLA-B27 resembles the B27-associated human spondyloarthropathies. Colitis and arthritis, the two most important features, require T cells, gut bacteria, and high expression of B27 in bone marrow-derived cells. Control rats with HLA-B7 remain healthy. Most rats with HLA-Cw6 (associated with psoriasis vulgaris) remain healthy; a minority develop...

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Identifiers

PMID: 10450519
DOI: 10.1111/j.1600-065x.1999.tb01317.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Inflammatory disease in HLA-B27 transgenic rats.PMID 10450519Read ↗

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