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Article

HLA B27 in health and disease: a double-edged sword?

1 Aug 2002

Abstract excerpt

The strong association of the HLA class 1 allele HLA B27 with ankylosing spondylitis (AS) has been recognized for over 25 yr, however the pathogenic mechanism linking HLA B27 with AS and other spondyloarthropathies remains a mystery. We now know that the principal natural function of HLA B27 is an immunologic one, namely to bind antigenic peptides and then present them to T lymphocytes. I have shown that HLA B27...

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Identifiers

PMID: 12154202
DOI: 10.1093/rheumatology/41.8.857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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HLA B27 in health and disease: a double-edged sword?PMID 12154202Read ↗

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