Article
Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.
Oncogene - 13 Apr 2000
Kasus-Jacobi A, Béréziat V, Perdereau D, Girard J, Burnol A F
Abstract excerpt
The molecular adapter Grb7 is likely to be implicated in the development of certain cancer types. In this study we show that Grb7 binds the insulin receptors, when they are activated and tyrosine phosphorylated. This interaction is documented by two-hybrid experiments, GST pull-down assays and in vivo coimmunoprecipitations. In addition, our results argue in favor of a preferential association between Grb7 and...
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