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Article

Grb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.

Journal of molecular recognition : JMR - 1 Nov 2013

Paudyal Prakash, Shrestha Sanjay, Madanayake Thushara, Shuster Charles B, Rohrschneider Larry R, Rowland Aaron, Lyons Barbara A

Abstract excerpt

Grb7 is an adaptor molecule mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. Grb7, along with Grb10 and Grb14, make up the Grb7 protein family. This protein family has been shown to be overexpressed in certain cancers and cancer cell lines. Grb7 and a receptor tyrosine kinase, ErbB2, are overexpressed in 20-30% of breast cancers. Grb7 overexpression has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24089360
DOI: 10.1002/jmr.2297
PMCID: PMC4096567

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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