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Article

14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.

The Biochemical journal - 1 Nov 1997

Furlanetto R W, Dey B R, Lopaczynski W, Nissley S P

Abstract excerpt

We have used a yeast two-hybrid system to identify proteins which bind to the cytosolic portion of the type 1 insulin-like growth factor (IGF) receptor (IGFIR) but not the insulin receptor (IR). This analysis identified 14-3-3beta and zeta proteins. 14-3-3beta also binds to the IGFIR but not the IR in vitro and 14-3-3-IGFIR complexes are present in insect cells overexpressing the IGFIR cytoplasmic domain. 14-3-3...

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Identifiers

PMID: 9581554
DOI: 10.1042/bj3270765
PMCID: PMC1218855

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