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Novel Cellular Functions of ATR for Therapeutic Targeting: Embryogenesis to Tumorigenesis

20 Jul 2023

Abstract excerpt

The DNA damage response (DDR) is recognized as having an important role in cancer growth and treatment. ATR (ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has shown significant therapeutic potential in cancer treatment. ATR inhibitors have shown anti-tumor effectiveness, not just as monotherapies but also in enhancing the effects of standard chemotherapy, radiation, and...

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PMID: 37511442
DOI: 10.3390/ijms241411684

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